Wu S, et al. - Researchers evaluated the mediation impact by brachial-ankle pulse wave velocity (baPWV) in the link between age and blood pressure (BP) in 17,862 participants without history of myocardial infarction, stroke, atrial fibrillation or flutter, or cancer and with baPWV and BP measurements from 2010 to 2016. By the mediation effect of baPWV, the observed rise in systolic BP was 0.47 mm Hg per 1 year older. They noted that the direct influence of aging on systolic BP was −0.07 mm Hg per 1 year older. Greater than the standard regression coefficient from baseline systolic BP to follow-up baPWV, 0.09 was reported as the standard regression coefficient from baseline baPWV to follow-up systolic BP. Overall, the positive link between aging and BP was mediated by arterial stiffness. Elevated BP might be preceded by arterial stiffness.