Matsuda Y - Experts demonstrated a review of the pathological age-related non-neoplastic changes in the exocrine pancreas such as pancreatic fatty replacement, lobulocentric pancreatic atrophy, pancreatic duct ectasia, and metaplasia of exocrine pancreas, as well as alterations in islet cells, since knowledge of age-related changes is significant to discover relevant prevention, detection, and treatment strategies for various diseases seen in elderly subjects. In old subjects, common pancreatic neoplasms such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms, and pancreatic ductal adenocarcinoma were addressed. In pancreatic carcinogenesis, age-related pathological alterations played a principal role via telomere dysfunction. Moreover, in order to elucidate the molecular mechanisms of pancreatic carcinogenesis in old subjects, additional studies are required.