Papadaki E, et al. - Using the multiecho spin echo (MESE) sequence, researchers evaluated the shape and regional variations in the rate of age-related myelin and water content changes in deep white matter (WM) regions. The study sample consisted of 90 healthy adults (aged 22–81 years). For older people, the rate of age-related changes in long T₂ and myelin water fraction [MWF] was higher and a significant increase or decline was first noted at 60–69 years, respectively. These changes among the elderly were more pronounced and followed an anterior-posterior pattern.