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Age modification of ozone associations with cardiovascular disease risk in adults: A potential role for soluble P-selectin and blood pressure

Journal of Thoracic Disease Aug 04, 2018

Day DB, et al. - Given a significant association between personal exposure to ozone and plasma soluble P-selectin (sCD62P, a platelet activation biomarker) and blood pressure has been reported in a previous study, researchers assessed if age modifies these associations in the same and additional adults. They obtained data from a similar additional study involving 71 healthy participants, aged 19-26 years, and pooled it with the data from the first study. Mechanistically, cardiovascular impacts of ozone appeared to be enhanced with increasing age. Pooled data demonstrated the association of a 10 ppb increase in 24-hour ozone exposure with increases in sCD62P and systolic blood pressure by 22.3% and 1.35 mmHg, respectively, at age 25. At age 40, these values were found to be increased to 48.6% and 4.98 mmHg, respectively.

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