Jud P, et al. - In this prospective observational study (observation time 7.96 ± 1.3 years) of 120 patients, researchers examined the relationship of homocysteine (HCY) with symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) regarding their long-time outcome and the age dependency of HCY, SDMA, and ADMA values in claudicant patients with lower extremity arterial disease. Cardiovascular mortality was assessed as the main outcome parameter. Observations revealed a significant correlation of age with HCY, SDMA, and ADMA. However, only age predicted cardiovascular death independently. Compared to younger subjects, older patients display higher values of HCY and SDMA indicating age-adjusted cutoff values of HCY and SDMA due to strong age dependency.