Nagel SN, et al. - Consecutive individuals with suspected pulmonary embolism (PE) referred from the emergency department for computed tomography pulmonary angiography (CTPA) were retrospectively assessed by the experts in order to contrast the age-dependent diagnostic performance of clinical scores and D-dimer testing to recognize individuals with suspected PE. One thousand consecutive patients were involved. In individuals < 50 years, the AUC and exactitudes were higher. In individuals ≥ 75 years, the AUC decreased by 11% with the optimal cutoff dropping 1.5 points for the classic Wells score (WS) and in both ≥ 65 years groups with a maximum decrease of the AUC of 9%, the optimal cutoff was 900 μg/L greater for D-dimer levels. The YEARS score played best amongst all groups in terms of accuracy. Important interaction with patient age in prediction models was exhibited by the classic WS and D-dimer levels. Therefore, in individuals < 50 years, the best performance was given by D-dimer measurement and clinical scores. Across all age groups, the YEARS score performed best and was therefore suggested.