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Age dependence of modern clinical risk groups for localized prostate cancer—A population-based study

Cancer Jan 29, 2020

Huynh-Le MP, Myklebust TA, Feng CH, et al. - Considering the possible value of age-specific incidence rates (ASIRs) by modern clinical risk groups for informing risk stratification efforts for screening, researchers conducted this cross-sectional population study analyzing men diagnosed with PCa in Norway from 2014 to 2017 (n = 20,356). The patients were assessed for their age, Gleason score (primary plus secondary), and clinical stage. Observations revealed significant association of older age with a higher Gleason score and more advanced disease. The ASIR of high-risk disease was nearly 6 times higher at the ages of 75 to 79 years than the ASIR at 55 to 59 years. Screening seems to be beneficial for healthy older men.
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