Redlich A, Luster M, Lorenz K, et al. - In pediatric patients with differentiated thyroid carcinoma (DTC), requiring risk-adapted individualized therapy and follow-up, following emerged as significant negative prognostic factors for event-free survival (EFS): age < 10 years at diagnosis, ATA high-risk level, and poor response to therapy.

• From the GPOH-MET registry, data of 354 patients with DTC was retrieved (median age at diagnosis 13.7 years, range 3.6-17.9) with lymph node and distant metastases in 74.3% and 24.5%, respectively.

• Observations revealed 10-years overall and event-free survival (EFS) rates of 98.9% and 78.1%, respectively.

• Patients with lymph node and distant metastases, positive postoperative thyroglobulin, incomplete resection, sequential surgeries to achieve total thyroidectomy, invasion of capsule and lymph vessels, infiltration of surrounding soft tissues, tumor multifocality, ATA intermediate- and high-risk group, and age < 10 years showed impaired EFS.