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Age at diagnosis and gender modify the risk of 9q22 and 14q13 polymorphisms for papillary thyroid carcinoma

Polish Journal of Endocrinology Aug 12, 2017

Kula D, et al. – The researchers examined the association of papillary thyroid cancer (PTC) risk with single nucleotide polymorphisms (SNPs) in FOXE1 (rs965513, rs1867277, rs1443434) and near the NKX2–1 locus (rs944289) in a Polish population. They approved the association between PTC and all analyzed SNPs. They also illustrated that patient–related factors modify the predisposition to PTC by increasing the risk for rs944289 per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
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