Thong M, Doege D, Koch-Gallenkamp L, et al. - Researchers conducted this study to determine the long-term disease-specific health-related quality of life of younger (< 50 years) survivors of colon and rectal cancer via comparing disease-specific functional deficits and symptoms 5 to 16 years postdiagnosis, stratified by age at diagnosis and by gender. Using data from the population-based CAncEr Survivorship–A multi-Regional study in collaboration with 5 population-based German cancer registries, they included 697 survivors of colon cancer and 479 survivors of rectal cancer. In general, lower functioning and higher symptom burden were evident among survivors of colon and rectal cancer diagnosed at < 50 years of age vs survivors diagnosed at an older age. When stratified by gender, female survivors of colon cancer vs male survivors of the same age, tended to report more concerns with hair loss but fewer sexual problems. Relative to male survivors, female survivors of rectal cancer of same age tended to report lower levels of sexual interest, in all age groups. These observations support adapting supportive care for survivors of colon and rectal cancer to improve their self-management of symptoms according to cancer type, age at diagnosis, and gender.