Lapner ST, et al. - The sensitivity, specificity and negative predictive value (NPV) of age-adjusted D-dimer (AADD) vs clinical probability-adjusted D-dimer (CPADD) in suspected pulmonary embolism (PE) was reported. They assembled a retrospective cohort of 3,500 consecutive cases imaged for suspected PE at two US emergency departments. The study findings suggested that CPADD modestly improved the specificity of D-dimer, however, it had a lower NPV than AADD. It was concluded that AADD seems preferable in this investigation.