Slingsby MHL, et al. - This study sought to assess the effects of regular aerobic exercise in late pre- and recent postmenopausal women by testing basal platelet reactivity and platelet sensitivity to prostacyclin and nitric oxide. Findings revealed cardioprotective aspects of regular aerobic exercise in pre- and postmenopausal women. It improved the regulation of platelet reactivity through an increased platelet sensitivity to prostacyclin, which might counterbalance the increased atherothrombotic risk associated with menopause.