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Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study

Cancer Feb 04, 2020

Kawakita D, Abdelaziz S, Chen Y, et al. - Head and neck cancer (HNC) survivors were compared with cancer-free individuals regarding the incidence of respiratory disease diagnoses. Further, risk factors for the respiratory disease were investigated among HNC survivors. The Utah Cancer Registry yielded data of patients with HNC diagnosed from 1996 to 2012 (n = 1,901). Each HNC survivor was matched to up to 5 cancer-free individuals from the general population (n = 7,796) by birth year, gender, birth state, and follow-up time. The analysis revealed a much higher risk of adverse respiratory outcomes among HNC survivors than the general population cohort. HNC survivors were at higher risks of respiratory infection (hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.40-1.90), chronic obstructive pulmonary diseases and bronchiectasis (HR, 2.65; 95% CI, 2.13-3.29), and aspiration pneumonitis (HR, 6.21; 95% CI, 3.98-9.68) more than 5 years following the cancer diagnosis. These findings suggest the necessity for multidisciplinary care to limit the occurrence of adverse respiratory outcomes among HNC survivors.
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