Moerenhout K, Allami B, Gkagkalis G, et al. - Researchers conducted all total knee arthroplasties (TKAs) by one senior surgeon, using the F.I.R.S.T. posterior-stabilized knee prosthesis (Symbios, CH), with a similar protocol and identical operating room set up in this case-control, retrospective chart review. Fifty-one TKAs performed with patient-specific cutting guides and conventional metal instruments were included in group A. Forty-nine TKAs performed with patient-specific cutting guides and patient-specific, single-use instrumentation were included in group B. They further assessed operation duration, number of instrumentation trays, and sterilization costs. As per the findings, the use of patient-specific, single-use instruments for TKA reduced the number of instrumentation trays by more than one-third and saved 36% in sterilization costs compared with conventional instrumentation. The total cost is significantly diminished whether fabrication costs of single-use instruments are included by the company. No operative time advantage was found for single-use instrumentation.