Baik M, Nam HS, Heo JH, et al. - In first-ever ischemic stroke (IS) or transient ischemic attack (TIA), researchers ascertained if there are variations in long-term all-cause and cardiovascular mortalities and IS recurrence based on the degree of liver fibrosis. From a prospective stroke cohort, 2,504 patients with first-ever IS or TIA were selected for this study. There were 231 (9.2%) advanced fibrosis patients. The cumulative all-cause and cardiovascular mortalities were 6.4 and 1.9% during a median follow-up of 1.2 years and IS recurrence was noted in 5.3%. The increased risk of all-cause mortality, cardiovascular mortality, and IS recurrence was associated with advanced fibrosis. The burden of liver fibrosis in first-ever IS or TIA is correlated with unfavorable long-term prognosis, including recurrent IS.