Yancey KL, et al. - Since recent evidence indicates inflammatory signatures of chronic rhinosinusitis (CRS) depend on age, researchers ascertained if age also influences quality-of-life (QOL) and postoperative outcomes. Between 2014 and 2018, retrospective analysis of prospectively gathered QOL data from 403 adults with medically refractory CRS who had functional endoscopic sinus surgery at a tertiary care medical center was carried out. Participants in the study were divided into young (18 to 39 years, n = 100), middle-aged (40 to 59 years, n = 172), and elderly (≥ 60 years, n = 131) groups. Age can play an important role in the pathophysiology of CRS, the burden of symptoms, and surgical outcomes. After surgery, elderly patients report minor improvements in QOL specific to the disease and general health. In the elderly population, CRS management must integrate age-dependent variations in the burden of symptoms and expectations into algorithms of treatment.