Adult height after gonadotropin‐releasing hormone agonist treatment in girls with early puberty: A meta‐analysis
Clinical Endocrinology May 15, 2020
Park HK, et al. - In this analysis of previously published reports, researchers investigated the impacts of gonadotropin‐releasing hormone (GnRH) agonist treatment on adult height and the factors correlated with adult height outcomes. In total, 14 studies identified from a search of electronic databases (AMED, EMBASE, MEDLINE and RISS) have been involved. Controlled studies of girls who developed puberty before 10 years of age and measurements of adult heights of individuals were chosen. Studies using only long‐acting GnRH agonists to suppress puberty have been involved. The mean age of the individuals ranged from 6.3 to 9.0 years. The meta‐analysis exhibited a pooled mean difference in adult height of 3.2 cm and a 95% confidence interval of 1.3 to 5.1 cm. The disparity in height between the treated subjects and controls was significantly correlated with treatment duration rather than age at treatment start or discrepancy between bone age and chronological age.
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