Wang CS, et al. - Researchers assessed whether frequently relapsing or steroid-dependent nephrotic syndrome in children could be effectively and safely treated by adrenocorticotropic hormone (ACTH). They randomly assigned (1:1) subjects aged 2–20 years old with frequently relapsing or steroid-dependent nephrotic syndrome to ACTH (repository corticotropin injection) treatment regimen (80 U/1.73 m² administered twice weekly for 6 months, followed by 40 U/1.73 m² administered twice weekly for 6 months) or no relapse-preventing treatment. These participants were enrolled from 16 sites in the United States. With regard to disease relapse prevention in pediatric nephrotic syndrome, inefficacy of ACTH was observed at 80 U/1.73 m² administered twice weekly.