• Profile
Close

Adrenocortical carcinoma: Patterns of care and role of adjuvant radiation therapy— A population-based study and review of the literature

Current Oncology Sep 04, 2017

Atallah S, et al. – The experience of a tertiary cancer centre in the management of adrenocortical carcinoma (ACC) treated over 40 years, was reviewed. To make treatment recommendations, the current data were insufficient. For better identification of optimum management, use of collaborative databases and consensus about diagnostic and therapeutic guidelines were warranted. Although requiring further research, adjuvant radiation therapy (RT) could be a reasonable option for R1 disease.

Methods

  • ACC patients treated between January 1974 and December 2013 were identified, in a retrospective chart review.
  • Moreover, the clinicians extracted patient demographics and tumour characteristics.
  • They gathered outcomes data, including dates and sites of failure, vital status, and cause of death.
  • Kaplan– Meier method was employed to estimate overall survival.
  • Moreover, a medline search using PubMed, Ovid, and embase was used to review the literature about the role of rt and any available management guidelines for acc.

Results

  • 39 had confirmed ACC, among 81 patients identified during the chart review.
  • Surgical resection was performed in 32 patients, including in 2 patients with M1 disease.
  • 16 received adjuvant systemic treatment (mitotane or concurrent chemoradiation), among those 32 patients.
  • In addition, only 6 patients received adjuvant RT, of whom 3 are still alive (2 living with distant failure).
  • 28 patients had died (72%), 10 were living (26%), and 1 had been lost to follow-up, at a median follow-up of 3.8 years.
  • 2 experienced local failure, and the rest, distant failure, among the 22 patients for whom failure data were available.

Full text available Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay