Shanka JJS, et al. - Researchers intended to evaluate the utility and safety of perfusion CT of individuals with severe traumatic brain injury (TBI) at hospital admission and to analyze whether early in-hospital mortality could be characterized with perfusion CT (PCT). A prospective cohort pilot study was designed to perform PCT on individuals with severe TBI at first imaging workup at hospital admission. A sum of 19 individuals (13 men [68.4%]; six women [31.6%]; mean age, 36.4 years; median, 27.5 years) were recruited in this study. The results showed that four patients (21%) died. Admission PCT changes suggesting brainstem death were sensitive (75%) and specific (100%) and had high positive (100%) and negative (93.75%) predictive value for correct classification early in-hospital mortality in the first 48 hours after admission. It was recorded that the admission PCT of individuals with severe TBI was useful and safe. In the first 48 hours of hospital admission Admission, PCT findings supported in correctly classifying early in-hospital mortality.