Westfechtel L, et al. – This systematic review and meta–analysis was performed to comprehensively assess and evaluate the available evidence from randomised controlled trials to investigate the efficacy of adjuvant systemic interferon after ablative treatment for anogenital warts (AGWs) to increase clearance and decrease recurrence rates. Researchers observed that the GRADE quality of the evidence ranged from ‘very low’ to ‘high’. The significantly higher efficacy of low–dose alpha–interferon compared with placebo was based on a single trial, and the confidence in the effect estimates rated as ‘low’. Overall, they gained no reliable evidence favouring the systemic use of interferon after ablative treatment of AGW.