Beavis AL, Yen TT, Stone RL, et al. - In this multi-institutional, retrospective cohort study, researchers contrasted the survival of women with early-stage endometrioid endometrial cancer (EEC) with lymphovascular space invasion (LVSI) treated postoperatively with observation (OBS), radiation (RAD, external beam and/or vaginal brachytherapy), or chemotherapy (CHEMO)+/−RAD. The sample consisted of women (n = 478), the median age was 64 years, with stage I or II EEC with LVSI who had hysterectomy+/−lymphadenectomy from 2005 to 2015 and received OBS, RAD, or CHEMO+/−RAD postoperatively. According to findings, adjuvant therapy improved PFS vs observation alone in early-stage EEC with LVSI. Adjuvant chemotherapy with or without radiation improved PFS vs observation or radiation alone in those with grade 3 EEC.