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Adjuvant therapies in the management of medication-related osteonecrosis of the jaws: Systematic review

Head & Neck Sep 18, 2019

de Souza Tolentino E, de Castro TF, Michellon FC, et al. - In the management of medication-related osteonecrosis of the jaws (MRONJ), researchers studied the effectiveness of hyperbaric oxygen (HBO), low-intensity laser (LIL), and platelet-rich plasma (PRP). The results obtained from this systematic review indicate that there was an improvement in 75.6% of the 41 patients submitted to HBO, with positive impacts on pain relief and reduced size and number of lesions at a faster rate, with better effects when the drug was stopped. For MRONJ treatment, these therapies served as secure and effective adjuvant modalities. The lack of randomized clinical trials demonstrates the need for more high-quality research on the topic.
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