Caspers CJI, et al. - This retrospective study investigated the outcome after curative treatment for sinonasal mucosal melanoma targeting the effect of adjuvant radiotherapy on recurrence and survival in who underwent surgical resection with curative intention. Yielded therapeutic outcomes appeared to be consistent with previous literature. It was discovered that postoperative radiotherapy exhibited a probable connection with improved local control regardless of advanced disease and positive margin status in the treatment group.

Methods

• The scheme of this research was a retrospective chart analysis.
• It was performed at the tertiary referral hospital.
• Eligible subjects included 51 patients with primary sinonasal mucosal melanoma who underwent surgical resection with curative intention between 1980 and 2016 at Erasmus Medical Center, Rotterdam.
• The primary outcome included the categorization of patients into 2 groups: Surgery alone and surgery with adjuvant radiotherapy.
• The Log-rank test aided in comparing the rates of recurrence and survival between treatment groups.
• A scrutiny was conducted of the predictors for treatment modality, recurrence and survival via multivariate statistical analysis.

Results

• The development of local recurrence was found in 23.5% cases and distant metastasis in 47.1% cases.
• It was determined that the estimated 5-year disease-free survival was 25.2%, and 5-year overall survival (OS) was 38.1%.
• Post-operative radiotherapy was recieved by 43 patients (84.3%).
• Individuals who underwent surgery with adjuvant radiotherapy exhibited a greater tendency for high tumour stage, tumour involving multiple sites and positive margins.
• A correlation was possibly found between the post-operative radiotherapy with better local control (P=.549).
• The occurrence of distant metastasis and OS remained unaffected.
• Results depicted that positive margin status served as an independent negative predictor for distant metastasis-free survival and overall survival.