Adjuvant radiation for positive margins in adult head and neck sarcomas is associated with improved survival: Analysis of the National Cancer Database
Head & Neck May 30, 2019
Cannon RB, et al. - Using the National Cancer Database (NCDB), researchers examined whether postoperative radiotherapy (PORT) improves overall survival (OS) in adult head and neck (H&N) sarcomas with a positive margin and how utilization has changed. The study sample consisted of 1142 patients in the NCDB from 2004-2013 with adult H&N sarcomas who underwent resection and had a positive margin. Having insurance, salivary gland primary site, high-risk histology, poor differentiation, and a macroscopic positive margin were factors significantly associated with the increased use of PORT. Treatment at a community-based facility has been an independent predictor of decreased OS. For adult H&N sarcoma patients with either a microscopic or macroscopic positive margin, PORT provides a significant survival benefit, however, PORT is underused. Treatment was associated with the increased use of PORT and improved survival outcomes in academic/research cancer programs.
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