Albuquerque K, et al. - Using a multi-institutional database, researchers examined the comparative benefit of adjuvant chemotherapy (CT) alone, radiation therapy alone (RT) or in combination (chemotherapy and radiation therapy [CRT]) with respect to recurrence-free survival (RFS) and overall survival (OS) in women with pelvis-limited (PL) endometrial carcinoma (EC) (stage IIIA, IIIB, and IIIC1). For this investigation, they analyzed 270 surgically staged women with PLEC. Findings revealed that treatment regimens including RT correlated with improved survival endpoints vs CT alone for surgically staged PL stage III EC. PLEC patients receiving RT or CRT had improved OS compared with CT. In the adjuvant management of stage III PLEC, RT should be considered an essential component.