Megwalu UC, et al. - In patients with locally invasive papillary thyroid carcinoma, researchers evaluated the impact of adjuvant external beam radiotherapy (EBRT) on survival. For this investigation, they performed propensity score analysis on 870 subjects with surgically resected T4 papillary thyroid carcinoma, identified between 1988 and 2013 in the Surveillance, Epidemiology, and End Results Database. Findings suggested an association of EBRT with worse overall survival (OS) and disease-specific survival (DSS). Subset analysis of patients with major extrathyroid invasion showed the association of EBRT with worse OS, but not with DSS. Adjuvant EBRT was not associated with a survival benefit in the initial management of locally invasive papillary thyroid cancer.