Foster CC, et al. - The association between receipt of adjuvant chemotherapy post-stereotactic body radiotherapy (SBRT) and overall survival (OS) for patients with T1-T3N0M0 non-small-cell lung cancer (NSCLC) was investigated using the National Cancer Database (NCDB). A median follow-up of 32.5 months was done in the cohort comprising 24,011 patients. Observations revealed that early stage NSCLC often fails distantly post-SBRT. Lower OS was observed in correlation with adjuvant chemotherapy for T1-3N0 NSCLC. For T1-3N0 NSCLC ≥ 4 cm, no association of adjuvant chemotherapy with OS was observed. After propensity-score matching, adjuvant chemotherapy was noted to be associated with lower OS.