Adiposity may predict survival in patients with advanced stage cancer treated with immunotherapy in phase 1 clinical trials
Cancer Nov 03, 2019
Martini DJ, Kline MR, Liu Y, et al. - Researchers retrospectively analyzed patients (n = 90) who received immunotherapy on phase 1 clinical trials at the Winship Cancer Institute in Atlanta, Georgia, from 2009 through 2017, to determine the link between types of fat and survival in these patients. Baseline BMI and radiographic images at the middle of the third lumbar vertebrae were collected. They calculated fat densities, which were changed to indices (subcutaneous fat index [SFI], intermuscular fat index [IFI], and visceral fat index [VFI]) after dividing by height in meters squared. Most of the patients were men and had received a diagnosis of melanoma (33%) or gastrointestinal cancers (22%). The median BMI, median SFI, median IFI, and the median VFI were 27.4 kg/m2, 62.78, 4.06, 40.53, respectively. Findings are suggestive of the possible link of increased BMI, increased SFI, and decreased IFI, with prolonged survival in patients with cancer managed with immunotherapy.
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