Rafiq R, El Haddaoui H, de Mutsert R, et al. - Since there is a lack of knowledge about the role of adiposity in the link between vitamin D and inflammation, researchers undertook this cross-sectional analysis of The Netherlands Epidemiology of Obesity Study, a population-based cohort analysis involving men and women aged 45 to 65 years, to examine the link of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin as well as the role of adiposity in this association. CRP, leptin and adiponectin were considered as main outcome measures. Findings revealed that the negative link of serum 25(OH)D with the pro-inflammatory CRP as well as leptin, and the positive link with the anti-inflammatory adiponectin, was largely explained by the measures of adiposity.