Rafiq R, El Haddaoui H, de Mutsert R, et al. - Researchers conducted this cross-sectional analysis of The Netherlands Epidemiology of Obesity Study (NEO), a population-based cohort study, to evaluate the correlation of serum 25-hydroxyvitamin D (25(OH)D) with C-reactive protein (CRP), leptin and adiponectin and the role of adiposity in this connection. Of the 6,287 candidates [mean (SD) age and BMI, respectively, were 56 (6) years and 26.3 (4.4) kg/m²], 21% were vitamin D deficient (serum 25(OH)D < 50 nmol/L). The authors found that adiposity tests largely clarified serum 25(OH)D's negative association with proinflammatory CRP and leptin, and the positive association with anti-inflammatory adiponectin. Such findings indicate that the adiposity effect will be taken into account in future research.