Signoriello E, et al. - This study assessed expression levels of both total adiponectin and its oligomerization state in the serum from 99 patients with multiple sclerosis (MS) at baseline (ie, not influenced by therapies). They also examined the potential associations of adiponectin with disease progression and severity. They reported that adiponectin and its HMW oligomers were deeply involved in MS autoimmune disorder, representing a potential biomarker to forecast worse MS prognosis and severity. Between active and inactive MS patients, and among the different forms of the disease, they did not find any statistical difference adiponectin expression.