Sasso FC, et al. - In a single-center prospective longitudinal observational study, the AIRE, researchers examined the association between adipokines plasma levels, insulin resistance (IR) and ischemic heart disease (IHD) in Normal Glucose Tolerance (NGT) patients undergoing Percutaneous Coronary Intervention (PCI). Participants were 54 patients without a history of diabetes and without Altered Fasting Glucose (AFG)/Impaired Fasting Glucose (IGT) after Oral Glucose Tolerance Test (OGTT). They found an independent association of adiponectin levels with restenosis. Findings also highlighted an independent association of HOMA-IR and adiponectin with both de novo IHD and overall new PCI. The estimated potential cut-off for adiponectin for risk of restenosis was ≤ 8.5 µg/mL and for overall new PCI was ≤ 9.5 µg/mL. A role of IR and cytokines in the progression of any stage of IHD was evident also in NGT subjects.