Agostinis-Sobrinho C, Ramírez-Vélez R, Norkiene S, et al. - In this longitudinal analysis, researchers sought to investigate markers of inflammation for their correlations with blood pressure levels over a two-year period in healthy adolescents. The sample consisted of 406 adolescents (209 girls) aged 12–18 years, followed up for 2 years in the LabMed Physical Activity Study. Anthropometric (weight, height, BMI), markers of inflammation (high sensitivity C-reactive protein, complement factors C3 and C4, fibrinogen, leptin, and adiponectin) and ambulatory blood pressure (BP) have been obtained. Even after adjusting confounding variables, L/A ratio was positively linked to systolic BP and diastolic BP. Consequently, a higher imbalance between leptin and adiponectin (higher L/A ratio) in early adolescence may have a negative impact on BP levels in late adolescence, irrespective of several confounders factors.