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Adequacy of scoring systems in diagnosing paediatric autoimmune hepatitis: Retrospective study using a control group children with hepatitis B infection

Acta Pediatrica Feb 06, 2019

Niță AF, et al. - In this retrospective study, researchers analyzed the adequacy of autoimmune hepatitis (AIH) diagnostic scoring systems in children by comparing adult scoring systems – the 1999 revised scoring system by International Autoimmune Hepatitis Group and the 2007 Simplified Scoring System. Both scoring systems were used for 28 children with AIH pre-treatment and 28 with Hepatitis B infection (HBV)– matched by sex and age, all diagnosed in an emergency children's hospital in Bucharest, Romania between 2010 and 2017. According to the 1999 revised score, AIH was present in 85.7% of cases, respectively 57.0% as per the 2007 simplified score. When AIH was correlated with another autoimmune disease, the 2007 simplified score resulted in false negative outcomes. Investigators observed that patients who did not undergo liver biopsy were related to a downgraded diagnosis by the 2007 simplified score. The findings suggested that a scoring system tailored to children's characteristics is needed. Liver biopsy and associated autoimmune disorders could be two compulsory components of the future score. The existing scores could be used in children for greater precision, preferably both at once and together with liver biopsy.
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