Bourdon M, Santulli P, Kateb F, et al. - A cohort study was performed to ascertain if the adenomyosis phenotype affects the proton nuclear magnetic resonance ( ¹ H-NMR)-based serum metabolic profile of patients. Researchers included 77 individuals who had undergone laparoscopy for a benign gynecologic condition. They detected serum metabolic variations in women with features of adenomyosis compared with their disease-free counterparts, and a number of specific metabolic pathways seem to be engaged according to the adenomyosis phenotype. The results demonstrate that metabolites with altered levels are especially involved in immune activation as well as cell proliferation and cell migration. However, this research did observe evidence of a relationship between metabolite levels and symptoms thought to be related to adenomyosis. Future trials are needed to ascertain the clinical significance of these differences in metabolic profiles.