Yu O, et al. - Researchers examined the incidence, 10-year secular trends, and prevalence of adenomyosis diagnoses in a large US cohort. Further, they reported symptoms and treatment patterns. In this retrospective population-based cohort study, they assessed 333,693 women aged 16-60 years of age in 2006-2015, who were enrolled in Kaiser Permanente Washington, a mixed-model health insurance and care delivery system. For incidence calculations, these women contributed 1,185,855 woman-years (2006-2015). Findings revealed a high adenomyosis burden to the individual and the health care system. The overall adenomyosis incidence of 1.03% or 28.9 per 10,000 woman-years was observed with a high of 30.6 in 2007 and a low of 24.4 in 2014. The highest incidence was reported for women 41-45 years (69.1 per 10,000 woman-years in 2008); the incidence was higher for black (highest 44.6 per 10,000 woman-years in 2011) vs white women (highest 27.9 per 10,000 woman-years in 2010). In 2015, they noted an overall prevalence of 0.8%. Findings revealed a high adenomyosis burden to the individual and the health care system. These findings are of interest, as currently available long-term medical therapies remain restricted beyond hysterectomy. The data and methodologies are new and seem to have implications for guiding clinicians and healthcare systems to generate clinical management plans and track results for women with adenomyosis.