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Addition of liver stiffness enhances the predictive accuracy of the PAGE‐B model for hepatitis B‐related hepatocellular carcinoma

Alimentary Pharmacology and Therapeutics Jan 23, 2021

Chon HY, Lee HA, Suh SJ, et al. - This study was sought to evaluate if the addition of liver stiffness (LS) value, measured via transient elastography, enhanced the predictive accuracies of the modified PAGE‐B (mPAGE‐B) and PAGE‐B models. Between 2007 and 2017, researchers included patients with chronic hepatitis B (CHB) who started anti‐viral therapy (AVT). They designed training (Yonsei University Hospital) and validation (seven Korean referral institutes) cohorts including 1,211 and 973 patients, respectively. The results showed that in Korean patients with CHB receiving AVT, the predictive accuracies of the PAGE‐B and modified PAGE‐B (mPAGE‐B) models were validated. Nevertheless, the modified PAGELS‐B model featuring the addition of LS value offered higher predictability vs the PAGE‐B and mPAGE‐B models. Compared to the intermediate‐risk (modified PAGELS‐B score 12‐24) or low‐risk (modified PAGELS‐B score < 12) group, the cumulative HCC incidence was significantly higher in the high‐risk (modified PAGE‐BLS score ≥ 24) group.

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