Rademacher J, et al. - A sum of 117 candidates were analyzed to examine the impact of adding biomarkers to routine clinical parameters on the prediction of radiographic spinal progression (worsening of the modified Stoke Ankylosing Spondylitis Spine Score by ⩾2 points after 2 years) in axial spondyloarthritis. Researchers observed the combination of 1 biomarker with potential added predictive value supplementary to the clinical model: leptin+high molecular weight adiponectin+VEGF. A non statistically significant improved predictive value in comparison with the clinical model indicated by AUCClinical+Biomarkers=0.768 was recorded with a combination of clinical parameters+biomarkers. Hence, they suggested an improvement in the prediction of radiographic spinal progression in axial spondyloarthritis.