Robba C, Banzato E, Rebora P, et al. - Polytrauma patients frequently develop acute kidney injury, which is associated with increased mortality and extended hospital length of stay among these patients. Researchers here examined a large cohort of traumatic brain injury patients for the occurrence rate, risk factors, timing, and association with outcome of acute kidney injury. For this multicenter, prospective observational, longitudinal, cohort study, named the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury, they selected a total of 4,509 traumatic brain injury patients with an ICU length of stay greater than 72 hours and with at least two serum creatinine values during the first 7 days of ICU stay. Of these, a total of 1,262 patients were included. Findings suggest that nearly one in 10 patients is affected by acute kidney injury after traumatic brain injury. Its occurrence was noted to have negative impacts on mortality and neurologic outcome at 6 months. A modifiable risk factor suggested was osmotic therapy use during ICU stay.