Lavergne A, et al. - Researchers reported a case series of 23 patients who developed acute kidney injury (AKI) during treatment with high doses cloxacillin, as recommended for endocarditis or osteomyelitis due to meticillin-susceptible staphylococci, to assess the tolerability of these regimens. They noted the occurrence of most cases during the first week of treatment, in elderly patients with cofactors for AKI, including hemodynamic instability, and nephrotoxic agents. Therapeutic drug monitoring of cloxacillin may assist in early recognition of trough plasma concentrations >50 ng/mL, and decrease the risk of AKI in patients treated with high-dose cloxacillin.