Chaudery H, et al. - Using multivariable logistic regression, researchers assessed the links among preoperative creatinine-based estimated glomerular filtration rate (eGFR), postoperative acute kidney injury (AKI), and hospital mortality, accounting for the influences of age, major comorbid diseases, and nature and severity of surgical intervention on results. For this purpose, planned analysis of data was collected during an international 7-day cohort study of adults undergoing elective in-patient surgery. Using Kidney Disease Improving Global Outcomes criteria, they defined AKI. Excluded cases included patients missing preoperative creatinine data. Findings revealed a strong association of the occurrence and severity of AKI with risk of death post-surgery. However, they found that the link between preoperative renal function as evaluated by serum creatinine-based eGFR and risk of mortality was dependent on patient age and if AKI develops postoperatively.