Klass M, et al. - The role of noradrenergic modulation in the control of motor output by comparing the acute effect of Reboxetine (REB), a noradrenaline reuptake inhibitor versus placebo (PLA) on knee extensors motor performance and cortical and spinal excitability in young males, was determined. A rise could be gained in the voluntary activation and accuracy in force control by an enhanced level of noradrenaline concentration. Improvement in motor performance was noted with changes located at the cortical and spinal levels.