Bozzani A, Arici V, Tavazzi G, et al. - This study was undertaken to present the experience of the Department of Vascular Surgery of Pavia (Lombardy), including the lessons learned and future perspectives regarding the management of COVID-19 patients who developed severe acute ischemia with impending lower limb loss or deep vein thrombosis (DVT). Researchers performed a retrospective data collection of COVID-19 patients with severe acute ischemia of the lower limbs or DVT observed in the Department during the period March 1st to April 30th, 2020. In this study, 38 patients (28 male) with severe COVID-19 infection (6 with lower limb arterial thrombosis and 32 with DVT) were observed. The results validate that critically ill, COVID-19 individuals who develop arterial and deep vein thrombosis are at high risk of mortality, but whether treated properly, there is an improvement in overall survival rate, particularly in patients of 60 years of age or younger.