Mörtsell D, et al. - Given that a single cryoballoon (CB) application per vein for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF) could save time, researchers compared this approach to the standard approach of two consecutive CB applications for acute and long-term efficacy and safety. Observations revealed that a single CB application shortened the procedure time without affecting acute or long-term efficacy, as compared to the routine two-application strategy, which with the lower complication rates had important implications when defining standards for PVI.