Gorvin CM, Stokes VJ, Boon H, et al. - Considering that autosomal dominant hypocalcemia types 1 and 2 (ADH1 and ADH2) are caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and its signaling partner, the G-protein subunit α₁₁ (Gα₁₁), respectively, researchers discovered two additional ADH families and examined them for CaSR and Gα₁₁ mutations. According to results, CaSR variants were not found, but 2 novel heterozygous germline Gα11 variants, p.Gly66Ser and p.Arg149His, have been identified. Such outcomes show that the Gα₁₁ interdomain interface represents a hotspot for germline gain-of-function mutations causing ADH2.