Tian LM, et al. - Researchers intended to determine if there is an association between the single nucleotide polymorphisms of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group. The sample consisted of 104 patients with acne vulgaris and 126 healthy participants. They analyzed the link between acne vulgaris and the polymorphisms in the DEFB1 G-52A, C-44G, and G-20A gene. The − 44G or − 20A allele exhibited a low expression in acne vulgaris, which has already been shown to associate with the low risk of acne vulgaris among Chinese Han patients. The contribution of the DEFB1 gene to the pathogenesis of acne is further confirmed by this.