Al-aroomi MA, Mashrah MA, Al-Aroomi OA, et al. - In the present study, the researchers sought to assess the effectiveness of acellular dermal matrix (ADM) to prevent Frey's syndrome (FS) after superficial parotidectomy of benign tumors and to evaluate the impact of different follow-up intervals on the incidence of FS. Fifty-five patients who underwent superficial parotidectomy with benign parotid gland tumors were classified into two groups: non-ADM (n = 31, 56.3%) and ADM (n = 24, 43.6%). The incidence of subjective and objective FS in ADM compared with non-ADM groups was statistically significantly different. In the ADM group, there were no cases of immune rejection, infection, hematoma, or salivary fistula. The current study showed that ADM could lessen the incidence of FS in the patients undergoing superficial parotidectomy. For the development of FS, the peak onset of about 18 months appear to be appropriate.