D'Andrea D, et al. - The current prognostic models for the selection of patients with T1G3 urothelial bladder cancer who are more likely to fail intravesical therapy and progress to muscle-invasive bladder cancer (MIBC) were studied. In a prognostic model for the prediction of MIBC, the results demonstrated the clinical value of the integration of lymphovascular invasion (LVI) and variant histology (VH). Superior individualized risk estimation of progression is provided in this tool facilitating decision-making for early radical cystectomy.