Accurate estimation of cardiovascular risk in a non-diabetic adult: Detecting and correcting the error in the reported Framingham Risk Score for the Systolic Blood Pressure Intervention Trial population
BMJ Open Jul 26, 2018
Warner F, et al. - Using the Framingham Risk Score for participants in the Systolic Blood Pressure Intervention Trial (SPRINT), researchers wanted to understand the discrepancy between the published 10-year cardiovascular risk and 10-year cardiovascular risk generated from raw data. The Framingham Risk Score indicated ≥ 15% 10-year cardiovascular risk for 7,089 participants compared with 5,737 reported in the paper, a change from 61% to 76% of the total study population. An error was identified in the reporting of the risk of the study population on analysis of the clinical trial data by independent investigators. The SPRINT trial enlisted a higher risk population than was reported in the initial publication, which was exposed by data sharing.
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